AAK1 Antibody, HRP conjugated | CSB-PA643571LB01HU

AAK1 Antibody, HRP conjugated | CSB-PA643571LB01HU | Cusabio

AAK1 Antibody, HRP conjugated is Available at Gentaur Genprice with the fastest delivery.

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Product Type: Polyclonal Antibody

Target Names: AAK1

Aliases: AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1), AAK1, KIAA1048

Background: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

Isotype: IgG

Conjugate: HRP

Clonality: Polyclonal

Uniport ID: Q2M2I8

Host Species: Rabbit

Species Reactivity: Human

Immunogen: Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)

Immunogen Species: Human

Applications: ELISA

Tested Applications: ELISA

Purification Method: >95%, Protein G purified

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Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form: Liquid

Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Initial Research Areas: Signal Transduction

Research Areas: Signal transduction