Cusabio Polyclonal Antibodies
YAP1 Antibody | CSB-PA026244LA11HU
- 3 to 7 Working Days
YAP1 Antibody | CSB-PA026244LA11HU | Cusabio
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Product Type: Polyclonal Antibody
Target Names: YAP1
Aliases: Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog), YAP1, YAP65
Background: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637) . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288) . Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702) . Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288) . The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750) .
Uniport ID: P46937
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Recombinant Human Transcriptional coactivator YAP1 protein (155-504AA)
Immunogen Species: Homo sapiens (Human)
Applications: ELISA, WB, IF
Tested Applications: ELISA, WB, IF; Recommended dilution: WB:1:1000-1:5000, IF:1:100-1:500
Purification Method: >95%, Protein G purified
Dilution Ratio1: WB:1:1000-1:5000
Dilution Ratio2: IF:1:100-1:500
Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Others
Research Areas: Others