Cusabio Polyclonal Antibodies
TP53 Antibody | CSB-PA150453
- SKU:
- CSB-PA150453
- Availability:
- 3 to 7 Working Days
Description
TP53 Antibody | CSB-PA150453 | Cusabio
TP53 Antibody is Available at Gentaur Genprice with the fastest delivery.
Online Order Payment is possible or send quotation to info@gentaur.com.
Product Type: Polyclonal Antibody
Target Names: TP53
Aliases: tumor protein p53
Background: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Isotype: IgG
Conjugate: Non-conjugated
Clonality: Polyclonal
Uniport ID: P04637
Host Species: Rabbit
Species Reactivity: Human
Immunogen: Fusion protein of human TP53
Immunogen Species: Human
Applications: ELISA, WB
Tested Applications: ELISA, WB;ELISA:1:1000-1:5000, WB:1:500-1:2000
Purification Method: Antigen affinity purification
Dilution Ratio1: ELISA:1:1000-1:5000
Dilution Ratio2: WB:1:500-1:2000
Dilution Ratio3:
Dilution Ratio4:
Dilution Ratio5:
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Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form: Liquid
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Cell Biology
Research Areas: Epigenetics & Nuclear Signaling;Cancer;Cell biology