Cusabio Rattus norvegicus Recombinants
Recombinant Rat Peripheral myelin protein 22 (Pmp22) | CSB-CF018241RA
- 3 - 7 Working Days
Recombinant Rat Peripheral myelin protein 22 (Pmp22) | CSB-CF018241RA | Cusabio
Alternative Name(s): Protein CD25 (SR13 myelin protein) (Schwann cell membrane glycoprotein) (SAG) (Cd25) (Pmp-22)
Gene Names: Pmp22
Research Areas: Neuroscience
Organism: Rattus norvegicus (Rat)
AA Sequence: MLLLLLGILFLHIAVLVLLFVSTIVSQWLVGNGHRTDLWQNCTTSALGAVQHCYSSSVSEWLQSVQATMILSVIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAAAIYTVRHSEWHVNNDYSYGFAYILAWVAFPLALLSGIIYVILRKRE
Source: in vitro E.coli expression system
Tag Info: N-terminal 10xHis-tagged
Expression Region: 1-160aa
Sequence Info: Full Length
MW: 23.4 kDa
Purity: Greater than 85% as determined by SDS-PAGE.
Relevance: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Reference: "Axon-regulated expression of a Schwann cell transcript that is homologous to a 'growth arrest-specific' gene." Spreyer P., Kuhn G., Hanemann C.O., Gillen C., Schaal H., Kuhn R., Lemke G., Mueller H.W. EMBO J. 10:3661-3668(1991)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Involvement in disease:
Subcellular Location: Cell membrane, Multi-pass membrane protein
Protein Families: PMP-22/EMP/MP20 family
Tissue Specificity: Found exclusively in the peripheral nervous system. Present in both myelinating and nonmyelinating Schwann cells. Found in the tumors of Schwann cell lineage where axons are present (neurofibromas) but not where axons are absent (schwannomas).
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P25094
HGNC Database Link: N/A
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: N/A