Recombinant Mouse Platelet glycoprotein VI (Gp6), partial | CSB-EP009689MO1

Recombinant Mouse Platelet glycoprotein VI (Gp6), partial | CSB-EP009689MO1 | Cusabio

Alternative Name(s): Glycoprotein 5

Gene Names: Gp6

Research Areas: Others

Organism: Mus musculus (Mouse)

AA Sequence: QSGPLPKPSLQAQPSSLVPLGQSVILRCQGPPDVDLYRLEKLKPEKYEDQDFLFIPTMERSNAGRYRCSYQNGSHWSLPSDQLELIATGVYAKPSLSAHPSSAVPQGRDVTLKCQSPYSFDEFVLYKEGDTGSYKRPEKWYRANFPIITVTAAHSGTYRCYSFSSSSPYLWSAPSDPLVLVVTGLSATPSQVPTEESFPVTESSRRPSILPTNKISTTEKPMNITASPEGLSPPFGFAHQHYAK

Source: E.coli

Tag Info: N-terminal 6xHis-SUMO-tagged

Expression Region: 22-265aa

Sequence Info: Extracellular Domain

MW: 43.0 kDa

Purity: Greater than 85% as determined by SDS-PAGE.

Relevance: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

Reference: "The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo." Munnix I.C., Strehl A., Kuijpers M.J., Auger J.M., van der Meijden P.E., van Zandvoort M.A., oude Egbrink M.G., Nieswandt B., Heemskerk J.W. Arterioscler. Thromb. Vasc. Biol. 25:2673-2678(2005)

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Function: Collagen receptor involved in collagen-induced platelet adhesion and activation

Involvement in disease:

Subcellular Location: Cell membrane, Single-pass membrane protein

Protein Families:

Tissue Specificity: Megakaryocytes and platelets.

Paythway:

Form: Liquid or Lyophilized powder

Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Uniprot ID: P0C191

HGNC Database Link: N/A

UniGene Database Link: UniGene

KEGG Database Link: KEGG

STRING Database Link: STRING

OMIM Database Link: N/A