Recombinant Human Protein Wnt-2 (WNT2) | CSB-YP026133HU
- 25 - 35 Working Days
Recombinant Human Protein Wnt-2 (WNT2) | CSB-YP026133HU | Cusabio
Alternative Name(s): Int-1-like protein 1 Int-1-related protein
Gene Names: WNT2
Research Areas: Stem Cells
Organism: Homo sapiens (Human)
AA Sequence: SWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCGCKFHWCCAVRCQDCLEALDVHTCKAPKNADWTTAT
Tag Info: N-terminal 6xHis-tagged
Expression Region: 26-360aa
Sequence Info: Full Length of Mature Protein
MW: 39.6 kDa
Purity: Greater than 90% as determined by SDS-PAGE.
Relevance: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Reference: "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus." Clement G., Braunschweig R., Pasquier N., Bosman F.T., Benhattar J. Oncogene 25:3084-3092(2006)
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Involvement in disease:
Subcellular Location: Secreted, extracellular space, extracellular matrix
Protein Families: Wnt family
Tissue Specificity: Expressed in brain in the thalamus, in fetal and adult lung and in placenta.
Form: Liquid or Lyophilized powder
Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Uniprot ID: P09544
HGNC Database Link: HGNC
UniGene Database Link: UniGene
KEGG Database Link: KEGG
STRING Database Link: STRING
OMIM Database Link: OMIM