Phospho-MAPT (Ser214) Antibody | CSB-PA135965
- 3 to 7 Working Days
Phospho-MAPT (Ser214) Antibody | CSB-PA135965 | Cusabio
Phospho-MAPT (Ser214) Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: MAPT
Aliases: MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
Background: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Smet C, et al. (2005) FEBS Lett; 579 (19) : 4159-64.
Puig B, et al. (2005) Acta Neuropathol (Berl) .
Gvtz J, et al. (2001) Science; 293 (5534) : 1491-5.
Illenberger S, et al. (1998) Mol Biol Cell; 9 (6) : 1495-512.
Uniport ID: P10636
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of serine 214 (T-P-S (p) -L-P) derived from Human Tau.
Immunogen Species: Human
Applications: ELISA, WB
Tested Applications: ELISA, WB;WB:1:500-1:1000
Purification Method: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Dilution Ratio1: ELISA:1:2000-1:10000
Dilution Ratio2: WB:1:500-1:1000
Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Neuroscience
Research Areas: Neuroscience;Signal transduction