MC1R Antibody | CSB-PA974732
- 3 to 7 Working Days
MC1R Antibody | CSB-PA974732 | Cusabio
MC1R Antibody is Available at Gentaur Genprice with the fastest delivery.
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Product Type: Polyclonal Antibody
Target Names: MC1R
Aliases: melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Background: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH) . The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Uniport ID: Q01726
Host Species: Rabbit
Species Reactivity: Human, Mouse
Immunogen: Synthetic peptide of human MC1R
Immunogen Species: Human
Applications: ELISA, WB
Tested Applications: ELISA, WB;ELISA:1:1000-1:5000, WB:1:500-1:2000
Purification Method: Antigen affinity purification
Dilution Ratio1: ELISA:1:1000-1:5000
Dilution Ratio2: WB:1:500-1:2000
Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Initial Research Areas: Neuroscience
Research Areas: Neuroscience;Metabolism